Professor Marais is the Director of the CRUK Manchester Institute at The University of Manchester and a Professor of Molecular Biology. He has advanced our understanding of the role of BRAF in cancer and in 2004 he validated mutant BRAF as a therapeutic target in melanoma. He has since pioneered translational research in melanoma, studying basic biology to understand the mechanisms of resistance to targeted therapies. He was a member of the 2012 winning team for the AACR Team Science Award for its cancer drug discovery programme and more recently has developed anticancer drugs that target RAF kinases. In 2017, he received the Translational and Clinical Research Award from The ARC Foundation Léopold Griffuel Awards and an Outstanding Research Award from The Society of Melanoma Research. His research has contributed to public health information regarding the use of sunscreen and the need to combine this with other sun avoidance strategies to reduce the risk of developing melanoma. Professor Marais continues to focus on understanding the pathological basis of melanoma to deliver benefit to patients.