After a PhD in the lab of Didier Trouche in Toulouse on the regulation of a histone acetyltransferase Tip60, Gaelle Legube joined the group of Asifa Akhtar at EMBL to work on dosage compensation in Drosophila. There, she started to use genome wide approaches and reported the first high resolution profile of the dosage compensation complex on the chromosome X using ChIP-chip. After obtaining a permanent position at the CNRS in France and spending few years as a staff scientist in the lab of D.Trouche, she started her own group at the Centre de Biologie Integrative (CBI) in Toulouse in 2011. She was awarded the Bronze medal from the CNRS for her initial work. More specifically, her lab developed an original system (called DIvA for DSB Inducible via AsiSI), to induce multiple sequence-specific DNA Double Strand Breaks (DSB) widespread across the genome. Using this system her lab investigates several uncovered aspects of the relationship between chromatin and DSB repair, mostly using genome wide approaches.