Douglas Hanahan is Director of the Swiss Institute for Experimental Cancer Research (ISREC) in the Swiss Federal Institute of Technology Lausanne (EPFL), and Co-Director of the new multi-institutional Swiss Cancer Center Leman that is based in Lausanne. Hanahan trained at MIT and Harvard University. He worked at Cold Spring Harbor Laboratory as a graduate student and then as a faculty member. Subsequently he spent twenty-one years in the Department of Biochemistry & Biophysics at UCSF before moving to EPFL in 2009. He is a Fellow of the American Academy of Arts & Sciences, a member of the US National Academies of Medicine and of Science, and the European Molecular Biology Organization. He received an honorary degree from the University of Dundee (2011) and an award for distinguished cancer research from the Fondazione San Salvatore (Lugano, Switzerland). In 2014, he was elected as a fellow of the Academy of the American Association for Cancer Research (AACR), and honored with the AACR’s Lifetime Achievement Award. The Hanahan lab’s research is focused on elucidating mechanisms of tumor development and progression in genetically engineered mouse models of human cancer, a field Hanahan has helped pioneer, with a particular focus on functional contributions of the disparate cell types of the tumor microenvironment, and on applying knowledge of mechanisms to guide combinatorial therapeutic strategies with promise to improve the treatment of human cancers.